Hypertension at the early stages of pregnancy
Women with high blood pressure (hypertension) at early stages of pregnancy are more likely to have babies with birth defects, irrespective of usually prescribed medicines for their condition.
Researches assumes that it is the basic hypertension, rather than use of hypotensive drugs in early pregnancy which increases risk of birth defects.
Angiotensin-converting enzyme (ACE) inhibitors is type of the antihypertensive treatment usually ordered to be engaged in a hypertension. It is already known that they have poisonous effect on fetuses in the second or third trimesters, but their effects on a fetus during the first trimester of mother is still not clear.
They have studied the data on 465 754 infantile mother to steams from Kaiser Permenenta Northern Californian area between 1995 and 2008. The data also was accessible, on which medicines have been ordered and distributed to these women.
The analysis has shown that women who used the ACE inhibitors in their first trimester, more possibly, will have a child with some form of birth defect in comparison with women who didn't have a hypertension or who didn't use the form of antihypertensive treatment.
However, the similar lifted risk has been found among women who used other hypotensive drugs and those with a hypertension who didn't take antihypertensive treatment.
Researchers conclusion: "Our finding assumes that it is probable the basic hypertension, rather than use of hypotensive drugs in the first trimester which increases risk of birth defects in posterity."
In the accompanying editorial professor Allen Mitchell from the Boston university says that - based on accessible researches - it would seem reasonable to come to conclusion in that first trimester that the exposure doesn't represent to the ACE inhibitors poses no greater threat of birth defects than another antihiypertensives, and that it is the basic hypertension which places a fetus in danger.
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